Basic Information
VIS ID
TVIS30016220
Fusion event
HIV-ARAP2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p14
Reference genome
GRCh37/hg19
Start
36203660/36202038 (Hg38)
End
36203809/36202038 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARAP2
miRNAs that regulate target gene
hsa-mir-101-3p ; hsa-mir-26b-5p ; hsa-mir-106b-5p ; hsa-mir-20a-5p ; hsa-mir-4703-5p ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-6071 ; hsa-mir-6828-3p ; hsa-mir-3144-3p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-582-5p ; hsa-mir-6847-3p ; hsa-mir-5186 ; hsa-mir-767-3p ; hsa-mir-4666a-3p ; hsa-mir-1255b-2-3p ; hsa-mir-338-5p ; hsa-mir-300 ; hsa-mir-381-3p ; hsa-mir-144-3p ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-623 ; hsa-mir-3682-5p ; hsa-mir-6883-3p ; hsa-mir-4699-3p ; hsa-mir-627-3p ; hsa-mir-204-5p ; hsa-mir-211-5p ; hsa-mir-1305 ; hsa-mir-335-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-12113/Upstream/7382370; hsa-mir-1243/Downstream/224328;
Nearest TSS
ENST00000502981/Upstream/40538; ENST00000502245/Downstream/8707;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/5478818, chr4-CpG: 100/Downstream/41971
Upstream sequence
AAAGACATTAAGTCAAATTTATGGCTTTTATTAATCCTGCCATTTAAGGCAATGAAAAACATACTTCTCAAATATTCTAAACAATCTCAAAGGAAAAAGT
Downstream sequence
taattactcatttttattcagctatttatttatccaattattCTTTTAAGAAGCAGAAGACTTTTAAACGATACAGTAACAAAATATTTTAGAGAGAGAA
Target sequence
ATAATCACCATGCTGTTCCAGATTCATCTGCCTTGTTTACATAGCCCTAAAGAATCACAGCATATTTTATGTTATTCCCTCCTCTAACCCTAACGAGACCCAATATTTTCTAGGACTACAATCTCCATACGtatttatttttatttatc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate