Basic Information
VIS ID
TVIS30016222
Fusion event
HIV-UBE2K integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p14
Reference genome
GRCh37/hg19
Start
39731056/39729436 (Hg38)
End
39730998/39729436 (Hg38)
Orient
-
Location type
Intronic
Target gene
UBE2K
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-26b-5p ; hsa-mir-186-5p ; hsa-mir-190a-3p ; hsa-mir-24-3p ; hsa-mir-155-3p ; hsa-mir-337-5p ; hsa-mir-4485-3p ; hsa-mir-4667-3p ; hsa-mir-4495 ; hsa-mir-4670-3p ; hsa-mir-379-3p ; hsa-mir-380-3p ; hsa-mir-411-3p ; hsa-mir-3679-3p ; hsa-mir-600 ; hsa-mir-6826-3p ; hsa-mir-1273e ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-3924 ; hsa-mir-6759-3p ; hsa-mir-3662 ; hsa-mir-4446-5p ; hsa-mir-374a-3p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-1250-3p ; hsa-mir-660-5p ; hsa-mir-4700-3p ; hsa-mir-1273d
Nearest miRNA
hsa-mir-12113/Upstream/317462; hsa-mir-1243/Downstream/772604;
Nearest TSS
ENST00000502981/Upstream/31108; ENST00000515550/Downstream/119125;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/30937, chr4-CpG: 23/Downstream/40623
Upstream sequence
tacttggttctttggattttcacagataccttgtatccaacatgtctcaaactgatttttcccctctccctcaaaccctgacttctcAATTCTTTGTTTC
Downstream sequence
CTTATCTTTATTATACTGTCATCCACCCAGCAAAAAATCCCCTCTTCTAAGATCATAGCTTTTAGTTAGTAACTAAGTCCTTTAGATTTTACTTCCTGTC
Target sequence
tgtctcaaactgatttttcccctctccctcaaaccctgacttctcAATTCTTTGTTTC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate