Basic Information
VIS ID
TVIS30016224
Fusion event
HIV-PDS5A integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p14
Reference genome
GRCh37/hg19
Start
39915472/39913852 (Hg38)
End
39915658/39913852 (Hg38)
Orient
+
Location type
Intronic
Target gene
PDS5A
miRNAs that regulate target gene
hsa-mir-130b-5p ; hsa-mir-93-3p ; hsa-mir-615-3p ; hsa-mir-128-3p ; hsa-mir-125b-5p ; hsa-let-7b-5p ; hsa-mir-5003-3p ; hsa-mir-335-3p ; hsa-mir-5089-3p ; hsa-mir-2115-3p ; hsa-mir-140-3p ; hsa-mir-499b-3p ; hsa-mir-499a-3p ; hsa-mir-302f ; hsa-mir-4282 ; hsa-mir-340-5p ; hsa-mir-376a-3p ; hsa-mir-376b-3p ; hsa-mir-3124-3p ; hsa-mir-5009-3p ; hsa-mir-1306-5p ; hsa-mir-6885-3p ; hsa-mir-4503 ; hsa-mir-6792-5p ; hsa-mir-4804-3p ; hsa-mir-4720-3p ; hsa-mir-944
Nearest miRNA
hsa-mir-12113/Upstream/501878; hsa-mir-1243/Downstream/588188;
Nearest TSS
ENST00000502981/Upstream/126; ENST00000515550/Downstream/14254;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/142163, chr4-CpG: 194/Downstream/62594
Upstream sequence
CCTAAGCTTTATTCACCAGATTACAGAAAATATCTTGAAACATTCTCAAGAAGATACTATTTCATATTTCTGCTTATAACTGTGAGAAGTTTAAAATATC
Downstream sequence
CTATAAAAACATCTATGAAGGACAAAGTTACAGTTACCACCCTAATAAGCTTACTTTATAGGAAATCTGCAATTTACGTTCCAACATAAACACACATCAA
Target sequence
ATATGTCCTCACTTACTATGCAGAAATTGATTTAATTTCATGTTAGATCATCTGGGTTTTTGCTCTTATTTCACACCCTCCCAACTGCTAATTTATGTCTACTTCACTGATTAATTGCATTCTATACATTGGTTATGGACACTGTACAAATATGAGACATACAATTCACTTCTAACATTAAGAACC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate