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TVIS30016225
Basic Information
VIS ID
TVIS30016225
Fusion event
HIV-TMEM33 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p13
Reference genome
GRCh37/hg19
Start
41944481/41942464 (Hg38)
End
41944291/41942464 (Hg38)
Orient
-
Location type
Intronic
Target gene
TMEM33
miRNAs that regulate target gene
hsa-mir-193b-3p
;
hsa-mir-155-5p
;
hsa-let-7b-5p
;
hsa-mir-615-3p
;
hsa-mir-328-3p
;
hsa-mir-191-5p
;
hsa-mir-590-3p
;
hsa-mir-4775
;
hsa-mir-4804-3p
;
hsa-mir-6513-5p
;
hsa-mir-887-5p
;
hsa-mir-3122
;
hsa-mir-3913-5p
;
hsa-mir-450a-1-3p
;
hsa-mir-6780a-5p
;
hsa-mir-6779-5p
;
hsa-mir-3689c
;
hsa-mir-3689b-3p
;
hsa-mir-3689a-3p
;
hsa-mir-30b-3p
;
hsa-mir-1273h-5p
;
hsa-mir-6788-5p
;
hsa-mir-30c-2-3p
;
hsa-mir-30c-1-3p
;
hsa-mir-4284
;
hsa-mir-24-3p
;
hsa-mir-342-3p
;
hsa-mir-1228-3p
;
hsa-mir-150-5p
;
hsa-mir-186-3p
;
hsa-mir-545-5p
;
hsa-mir-335-3p
;
hsa-mir-1305
;
hsa-mir-4720-3p
;
hsa-mir-4635
;
hsa-mir-580-5p
;
hsa-mir-1273a
;
hsa-mir-4252
;
hsa-mir-212-5p
;
hsa-mir-3120-5p
;
hsa-mir-3664-5p
;
hsa-mir-4522
;
hsa-mir-4524a-3p
;
hsa-mir-6510-3p
;
hsa-mir-6888-3p
;
hsa-mir-1273d
;
hsa-mir-1273f
;
hsa-mir-143-3p
;
hsa-mir-1827
;
hsa-mir-1910-3p
;
hsa-mir-2467-3p
;
hsa-mir-25-3p
;
hsa-mir-3130-3p
;
hsa-mir-3160-3p
;
hsa-mir-32-5p
;
hsa-mir-3612
;
hsa-mir-363-3p
;
hsa-mir-367-3p
;
hsa-mir-377-5p
;
hsa-mir-4257
;
hsa-mir-4325
;
hsa-mir-4459
;
hsa-mir-4487
;
hsa-mir-4497
;
hsa-mir-455-3p
;
hsa-mir-4695-5p
;
hsa-mir-4708-5p
;
hsa-mir-4770
;
hsa-mir-552-5p
;
hsa-mir-558
;
hsa-mir-566
;
hsa-mir-583
;
hsa-mir-6086
;
hsa-mir-6088
;
hsa-mir-6499-3p
;
hsa-mir-650
;
hsa-mir-6511a-5p
;
hsa-mir-6516-5p
;
hsa-mir-652-3p
;
hsa-mir-665
;
hsa-mir-6789-3p
;
hsa-mir-6807-5p
;
hsa-mir-6840-3p
;
hsa-mir-7703
;
hsa-mir-92a-3p
;
hsa-mir-92b-3p
;
hsa-mir-95-3p
Nearest miRNA
hsa-mir-12113/Upstream/1440345; hsa-mir-1243/Downstream/5710205;
Nearest TSS
ENST00000502981/Upstream/3209;
ENST00000333141/Downstream/39232;
Nearest CpG islands
None/Target,
chr4-CpG: 46/Upstream/6857
,
chr4-CpG: 21/Downstream/39441
Upstream sequence
AACTATATTAGGGAGTTAGGGTTCTTCTAATACTTGGATATAGGTTGGTGTCTTGCTTGTCAATTGGAAACTGGGACCCTTGAATTCCTAAATGAGTTAT
Downstream sequence
GGTTATAATGAATTTGATACTCAGATTATGTTACAGCAATCACTATTTCCTGTCATATTAGGCCTTCAGTTAGTATAGAAAAATACAATGGTTCATTTCT
Target sequence
TATACATATATGATCTCTACTTAGGAAATGGACATTTTTCTTAATTCTTGTTAGAGGTGGGAATGAGTTGGTCAGGATATTAATTTGGAGAACTATATTAGGGAGTTAGGGTTCTTCTAATACTTGGATATAGGTTGGTGTCTTGCTTGTCAATTGGAAACTGGGACCCTTGAATTCCTAAATGAGTTAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT3
Sample type
PBMC
Age
52
Gender
Male
CpG Island Information
×
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