Basic Information
VIS ID
TVIS30016230
Fusion event
HIV-FRYL integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p11
Reference genome
GRCh37/hg19
Start
48613271/48611254 (Hg38)
End
48613173/48611254 (Hg38)
Orient
-
Location type
Intronic
Target gene
FRYL
miRNAs that regulate target gene
hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-1261 ; hsa-mir-128-3p ; hsa-mir-216a-3p ; hsa-mir-224-5p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-3171 ; hsa-mir-3681-3p ; hsa-mir-3681-5p ; hsa-mir-376b-5p ; hsa-mir-376c-5p ; hsa-mir-6849-5p
Nearest miRNA
hsa-mir-12113/Upstream/958511; hsa-mir-1243/Downstream/4101428;
Nearest TSS
ENST00000502981/Upstream/5408; ENST00000511662/Downstream/23156;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/119682, chr4-CpG: 121/Downstream/168060
Upstream sequence
aaaatggtgtagtatttgcatataacactacatacatcctcccgtacactttaaatcatctctatctagattacttatagtatgtaacacaatgtaaatg
Downstream sequence
ttacataaatagttgttatactgtattTCCTATTATtttttattattgtattgttacttttatttatatatattgttttaatttttaattttTGTGTGTA
Target sequence
aatggtgtagtatttgcatataacactacatacatcctcccgtacactttaaatcatctctatctagattacttatagtatgtaacacaatgtaaatg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate