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TVIS30016231
Basic Information
VIS ID
TVIS30016231
Fusion event
HIV-REST integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q12
Reference genome
GRCh37/hg19
Start
57776708/56910542 (Hg38)
End
57776765/56910542 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4B
Target gene
REST
miRNAs that regulate target gene
hsa-mir-9-5p
;
hsa-mir-21-5p
;
hsa-mir-335-5p
;
hsa-mir-124-3p
;
hsa-mir-3609
;
hsa-mir-548ah-5p
;
hsa-mir-17-5p
;
hsa-mir-20a-5p
;
hsa-mir-93-5p
;
hsa-mir-106a-5p
;
hsa-mir-106b-5p
;
hsa-mir-302a-3p
;
hsa-mir-302b-3p
;
hsa-mir-302c-3p
;
hsa-mir-302d-3p
;
hsa-mir-372-3p
;
hsa-mir-373-3p
;
hsa-mir-20b-5p
;
hsa-mir-520e
;
hsa-mir-520a-3p
;
hsa-mir-526b-3p
;
hsa-mir-520b
;
hsa-mir-520c-3p
;
hsa-mir-519d-3p
;
hsa-mir-520d-3p
;
hsa-mir-302e
;
hsa-mir-4690-5p
;
hsa-mir-4742-5p
;
hsa-mir-29a-3p
;
hsa-mir-29b-3p
;
hsa-mir-29c-3p
;
hsa-mir-6835-3p
;
hsa-mir-142-5p
;
hsa-mir-190a-3p
;
hsa-mir-4693-5p
;
hsa-mir-4796-3p
;
hsa-mir-5590-3p
;
hsa-mir-125b-5p
;
hsa-mir-125a-5p
;
hsa-mir-620
;
hsa-mir-670-5p
;
hsa-mir-548l
;
hsa-mir-1270
;
hsa-mir-4319
;
hsa-mir-4324
;
hsa-mir-4251
;
hsa-mir-4531
;
hsa-mir-4683
;
hsa-mir-362-3p
;
hsa-mir-329-3p
;
hsa-mir-105-5p
;
hsa-mir-4719
;
hsa-mir-7853-5p
;
hsa-mir-562
;
hsa-mir-646
;
hsa-mir-548n
;
hsa-mir-4323
;
hsa-mir-3653-3p
;
hsa-mir-4660
;
hsa-mir-641
;
hsa-mir-3617-5p
;
hsa-mir-4802-3p
;
hsa-mir-4422
;
hsa-mir-4752
;
hsa-mir-6833-5p
;
hsa-mir-7847-3p
;
hsa-mir-539-5p
;
hsa-mir-4638-3p
;
hsa-mir-4732-3p
;
hsa-mir-345-3p
;
hsa-mir-548c-3p
;
hsa-mir-378b
;
hsa-mir-378a-3p
;
hsa-mir-378f
;
hsa-mir-378h
;
hsa-mir-378i
;
hsa-mir-378e
;
hsa-mir-378c
;
hsa-mir-422a
;
hsa-mir-378d
;
hsa-mir-9-3p
;
hsa-mir-5703
;
hsa-mir-4434
;
hsa-mir-4516
;
hsa-mir-494-3p
;
hsa-mir-7844-5p
;
hsa-mir-6083
;
hsa-mir-676-5p
;
hsa-mir-302a-5p
;
hsa-mir-421
;
hsa-mir-7159-5p
;
hsa-mir-138-2-3p
;
hsa-mir-892c-3p
;
hsa-mir-4676-3p
;
hsa-mir-452-5p
;
hsa-mir-505-3p
;
hsa-mir-4668-5p
;
hsa-mir-6769a-3p
;
hsa-mir-3943
;
hsa-mir-410-3p
Nearest miRNA
hsa-mir-12113/Upstream/4197795; hsa-mir-1243/Downstream/4012077;
Nearest TSS
ENST00000502981/Upstream/1352;
ENST00000514063/Downstream/670;
Nearest CpG islands
None/Target,
chr4-CpG: 46/Upstream/1106
,
chr4-CpG: 109/Downstream/65926
Upstream sequence
TTGCAGTAGACTATTGGGAATTAACAACTATTTTAAAGATTTGTTTTTAATAGGCGATGAAGTTTACTGAGTTATAAAGATCATACTGGAAAATTTTTAA
Downstream sequence
TGCTCTTGTTTTGTTTTGTTTTTAATTCAGAATACAGTTATGGCCACCCAGGTAATGGGGCAGTCTTCTGGAGGAGGAGGGCTGTTTACCAGCAGTGGCA
Target sequence
GTTATGAAGAATTACAGCGATGTGGTTTTAAGCCAGTAACAGTAGTGTTTAAACTGG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT3
Sample type
PBMC
Age
52
Gender
Male
CpG Island Information
×
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