Basic Information
VIS ID
TVIS30016236
Fusion event
HIV-COQ2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q21.23
Reference genome
GRCh37/hg19
Start
84147160/83226007 (Hg38)
End
84147542/83226007 (Hg38)
Orient
+
Location type
Intronic
Target gene
COQ2
miRNAs that regulate target gene
hsa-mir-99a-5p ; hsa-mir-93-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-12113/Upstream/472577; hsa-mir-1243/Downstream/2496461;
Nearest TSS
ENST00000502981/Upstream/88932; ENST00000512375/Downstream/21206;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/115851, chr4-CpG: 71/Downstream/58221
Nearby gene
COQ2(No orient, 37816)
Upstream sequence
actcagccttctacagcatatctctggggatatatttacccacatttgagaaacaGCACCTTGAATTATGTATAATAAAATGAAGATGTTAACACTTACG
Downstream sequence
tactattaatttttagatataaaaagggtattgtttatgtatgagactgtctatatttctaggagaagattaatgtattaatatttataggtgaagtgtc
Target sequence
AAGTCTCAATAAATTCTTTGGCTATTTTTGTAAAGAAAACTAAAGAACTTTTCCAGGATCTATCTATATATCGTCTGTCTTTCTGTTTCCCGATGGTGAcaaagaatcactccacagattgttcactaattgcaaaaagaaaagaactgttaccatagagagacctggcactcaccatcttaaccaagtgctcaaaCAGTGTCCTTAACACCTAATGGAGCATTCCAATCTTATGGGGAAAAAAGCaggggaact
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate