Basic Information
VIS ID
TVIS30016238
Fusion event
HIV-NFKB1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q24
Reference genome
GRCh37/hg19
Start
103429720/102508563 (Hg38)
End
103429626/102508563 (Hg38)
Orient
-
Location type
Intronic
Target gene
NFKB1
miRNAs that regulate target gene
hsa-mir-9-5p ; hsa-mir-146a-5p ; hsa-mir-146b-5p ; hsa-mir-15a-5p ; hsa-let-7a-5p ; hsa-mir-16-5p ; hsa-mir-21-5p ; hsa-mir-155-5p ; hsa-mir-26b-5p ; hsa-mir-92a-3p ; hsa-mir-508-3p ; hsa-mir-199a-5p ; hsa-mir-139-5p ; hsa-mir-138-5p ; hsa-mir-9-3p ; hsa-mir-339-3p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-12113/Upstream/1178149; hsa-mir-1243/Downstream/6980135;
Nearest TSS
ENST00000502981/Upstream/5188; ENST00000502367/Downstream/29024;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/6491, chr4-CpG: 54/Downstream/252116
Nearest cancer related gene
NFKB1(TSG, No orient, 0)
Upstream sequence
TCAGCAATTGATTTACGTAAAATCAAAACTGAAAACTGAATATACAATCTAGGAAATAGGAAAAAAATTTTTAGTGTGTTCATACTGCTAATTTCAAACC
Downstream sequence
AAGCAAAAAACCTGGGGAACTACTTTTCAGAGGAGATGGCTTAAAATGAACCAAAAATATAGCCATTTCTCTACCCTATTCATTTAATGCATTCATTTAT
Target sequence
ATTGATTTACGTAAAATCAAAACTGAAAACTGAATATACAATCTAGGAAATAGGAAAAAAATTTTTAGTGTGTTCATACTGCTAATTTCAAACC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate