Basic Information
VIS ID
TVIS30016241
Fusion event
HIV-PPA2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q24
Reference genome
GRCh37/hg19
Start
106351832/105430675 (Hg38)
End
106351707/105430675 (Hg38)
Orient
-
Location type
Intronic
Target gene
PPA2
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-1-3p
Nearest miRNA
hsa-mir-12113/Upstream/4100261; hsa-mir-1243/Downstream/4058023;
Nearest TSS
ENST00000502981/Upstream/31039; ENST00000265154/Downstream/18696;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/283864, chr4-CpG: 82/Downstream/42719
Upstream sequence
AGCTGTGCCTTCTTCATTTCCAATGCCACTGCCCTGATCTAGGCAACAGAGTGTCAAGGTAGGTTCTCTAATATGATAAAAGGACAAGATAGAGGCTAAC
Downstream sequence
AAATCAGAAGACTATAACACTATAGATATGAGGTAATTTGGATCTAGATTAGGGACATGACAGTGGATAGTCTAGATAAGGGTAGTGAAATATTTATAAG
Target sequence
CAACACTACGTGCATCATTTCTCATAGCTGTGCCTTCTTCATTTCCAATGCCACTGCCCTGATCTAGGCAACAGAGTGTCAAGGTAGGTTCTCTAATATGATAAAAGGACAAGATAGAGGCTAAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate