Basic Information
VIS ID
TVIS30016242
Fusion event
HIV-TBCK integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q24
Reference genome
GRCh37/hg19
Start
107146594/106225437 (Hg38)
End
107146635/106225437 (Hg38)
Orient
+
Location type
Intronic
Target gene
TBCK
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-337-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-6740-5p ; hsa-mir-6729-3p ; hsa-mir-6780b-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-6741-5p ; hsa-mir-6736-5p ; hsa-mir-4701-3p ; hsa-mir-1262 ; hsa-mir-1284 ; hsa-mir-202-5p ; hsa-mir-4436b-5p ; hsa-mir-223-5p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-567 ; hsa-mir-574-5p ; hsa-mir-6867-5p
Nearest miRNA
hsa-mir-12113/Upstream/4895023; hsa-mir-1243/Downstream/3263261;
Nearest TSS
ENST00000502981/Upstream/11666; ENST00000510207/Downstream/5009;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/328825, chr4-CpG: 61/Downstream/809961
Upstream sequence
AATTATTAATACTTAGAGAAACAAGCAATCAATAATTGTTGAGAGGTCTTTTAATTATAATATTGGATGTTAAAATGTATTACTGATAAAATTGATCAAA
Downstream sequence
agacggagtctcgctctgtcacccaggctggagtgcagtggcgcaatctcggttcactgcaagctctacctcccaggttcaagtgattctcctgcctcag
Target sequence
CTAAAGAACAGTCtttttggtcttttttttgtttgtttttg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate