Basic Information
VIS ID
TVIS30016246
Fusion event
HIV-AP1AR integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q25
Reference genome
GRCh37/hg19
Start
113175851/112254695 (Hg38)
End
113175535/112254695 (Hg38)
Orient
-
Location type
Intronic
Target gene
AP1AR
miRNAs that regulate target gene
hsa-mir-93-5p ; hsa-mir-21-5p ; hsa-mir-4778-3p ; hsa-mir-190a-3p ; hsa-mir-302a-5p ; hsa-mir-5011-5p ; hsa-mir-141-5p ; hsa-mir-1277-5p
Nearest miRNA
hsa-mir-12113/Upstream/1394048; hsa-mir-1243/Downstream/393179;
Nearest TSS
ENST00000502981/Upstream/22806; ENST00000512741/Downstream/10357;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/22195, chr4-CpG: 50/Downstream/30981
Upstream sequence
aatgaaatgatgtattaaagaggcatttgaattaaatagcttacaaatataaaggtatattatttttAAGTGAAAAAAGTAACATAATTTCTTGTGAGAT
Downstream sequence
GTATACCTAAGACAAATATTCCTCTTAACGCTTACTTTTTTGTCCTTTCAGTTTGAGAATCTAGTAGAAAGTGATGAAGTAAGTATTTCCATAATAGTAC
Target sequence
CTTACAACATTTGTTCTGTAGTCAAGTGAAGTGGAATATTCTGGTAGCATGGAATGAAATTACTTGTATGAAATATTCAATTCAGATGAAAGTTTTAGTTCTGATTTATGTAGAAAATTGCTATAATTCTCCTGTTTGATTTTCATTCATAGAAAGTCATaaattaaaatagtatatgcttgtcttggccattttgtaggactgttaaatatatcaaatgaaatgatgtattaaagaggcatttgaattaaatag
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate