Basic Information
VIS ID
TVIS30016252
Fusion event
HIV-INPP4B integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.21
Reference genome
GRCh37/hg19
Start
143619341/142698188 (Hg38)
End
143619316/142698188 (Hg38)
Orient
-
Location type
Intronic
Target gene
INPP4B
miRNAs that regulate target gene
hsa-mir-222-3p ; hsa-mir-181a-5p ; hsa-mir-765
Nearest miRNA
hsa-mir-12113/Upstream/17190881; hsa-mir-1305/Downstream/645272;
Nearest TSS
ENST00000502981/Upstream/132169; ENST00000510377/Downstream/68631;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1061018, chr4-CpG: 111/Downstream/147599
Nearest cancer related gene
INPP4B(TSG, No orient, 0)
Upstream sequence
AAACACTCAAGCTGAAATAAATCTTGGCTGTAATTAAGATAAGTAACCACAGCTATAGGGCTACTGTTAGCATGAACATGCCCTTACCAGTAAGAGAAAA
Downstream sequence
CAATTAAGTTACAGATCTTACAAGTTATAAACAATTTTTTTCTGAAACAAATCCATCATTTTTATTGATTTGAAATCAATAGAGTTTTCATAAATTATTT
Target sequence
ACATGCCCTTACCAGTAAGAGAAAA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate