Basic Information
VIS ID
TVIS30016256
Fusion event
HIV-ARHGAP10 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.23
Reference genome
GRCh37/hg19
Start
148852044/147930893 (Hg38)
End
148852318/147930893 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARHGAP10
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-mir-214-3p
Nearest miRNA
hsa-mir-12113/Upstream/148225; hsa-mir-1305/Downstream/4558434;
Nearest TSS
ENST00000502981/Upstream/49026; ENST00000513548/Downstream/15346;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/198126, chr4-CpG: 294/Downstream/511167
Upstream sequence
GCCAGCTGTAGCTACTCTAGCCTTTATCTCTACCTCTCTTGTTTACCTGCATTTATCAGCCCTCTTAAGTTTTATTTTTCTTTTGCATCTGATTTTTTAA
Downstream sequence
TGGTAGGAAGTAAGACACATTTGATTTTACCTTATCCATTTTGCCCAGAGACAGCTGTCATCAGCTGCTCATCACTCTAATGGAGATAAGCTTACCTTTT
Target sequence
CTATCCCAGAACATCTTATTTTCTGTGTTGCTTCTCCAGCCCACCTACAGGGACAGTGGATGCCTGCTAGTGCTCAGTAGTTCCATGCAGGTGTTTTCTGGAGCTGTGTGGTCTCTGGCTCTGGTAACACCATTTGGGTTTGAGAGGGAAACAGCTGAGCAGAGATGATGATGAAACTTGACTGCTTCCCACTTTTTGACCCTCTCCTCTAGGAAGATGTGGGTGATGTGAGTAGTGCTCTATGACAGTGTTGTG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate