Basic Information
VIS ID
TVIS30016257
Fusion event
HIV-LRBA integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
151248182/150327030 (Hg38)
End
151248238/150327030 (Hg38)
Orient
+
Location type
Intronic
Target gene
LRBA
miRNAs that regulate target gene
hsa-mir-1229-3p ; hsa-mir-93-3p ; hsa-mir-769-5p ; hsa-mir-615-3p
Nearest miRNA
hsa-mir-12113/Upstream/2544362; hsa-mir-1305/Downstream/2162297;
Nearest TSS
ENST00000502981/Upstream/11396; ENST00000507934/Downstream/252059;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/247476, chr4-CpG: 62/Downstream/252581
Upstream sequence
GATCATTTTCAGAACATCATCTCAAATATTTTCTGATAGAGTGAAATTAATTTATGATTAAACATCAAGAACAAGCTTGAGAAAAAAATCATAAAATGGG
Downstream sequence
ATATATGAACTTATGGACTTAGTTTATGAATGAGAACTTTATATCTTTTTGAAGAACAGCTGGTAAGGATgggcatgatggctcacacctgtaatcccaa
Target sequence
AACCTGAAGGCTAAAGGTAGTCACAAAGAAGGAGGTAGCAACACTGCTAATTTATG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate