Basic Information
VIS ID
TVIS30016262
Fusion event
HIV-TMEM131L integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
154453089/153531937 (Hg38)
End
154453125/153531937 (Hg38)
Orient
+
Location type
Intronic
Target gene
TMEM131L
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-26b-5p ; hsa-mir-744-5p ; hsa-mir-335-3p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-5007-3p ; hsa-mir-5092 ; hsa-mir-3163 ; hsa-mir-513b-3p ; hsa-mir-548n ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-606 ; hsa-mir-4684-5p ; hsa-mir-3675-3p ; hsa-mir-4724-5p ; hsa-mir-216b-5p ; hsa-mir-3150b-5p ; hsa-mir-3150a-5p
Nearest miRNA
hsa-mir-12113/Upstream/995421; hsa-mir-1305/Downstream/5596865;
Nearest TSS
ENST00000502981/Upstream/65588; ENST00000462540/Downstream/22244;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/64474, chr4-CpG: 95/Downstream/151997
Upstream sequence
AAGGATCACATGTCTGGTGTAAGCACTTGTTCTTCTCTTATTCTATTTCCCCACCTCTCCACCACCTCCCCACCAAACCCCAGTCCTGATTTCTGCCCTT
Downstream sequence
CAGATGAAGAAGGAAATCACCATTGTTCTCCAGTCTAGTAGAGCCTGCTTGATTGAAATTGATTAGCTCTAGATGATTGGAGTCCTTGTAGCAGCAGGGG
Target sequence
CTCTTCATCTTCTGGCCCTTTTAAGGTGCATGCTAA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate