Basic Information
VIS ID
TVIS30016263
Fusion event
HIV-SEMA5A integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
9319640/9319528 (Hg38)
End
9319821/9319528 (Hg38)
Orient
+
Location type
Intronic
Target gene
SEMA5A
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-218-5p ; hsa-mir-6811-5p ; hsa-mir-6511b-5p ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6836-5p ; hsa-mir-6132 ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-100-3p ; hsa-mir-4270 ; hsa-mir-4709-3p ; hsa-mir-4645-3p ; hsa-mir-3185 ; hsa-mir-144-3p ; hsa-mir-8077 ; hsa-mir-496 ; hsa-mir-216a-5p ; hsa-mir-548c-3p ; hsa-mir-4695-3p ; hsa-mir-4772-3p ; hsa-mir-6787-3p ; hsa-mir-1304-3p ; hsa-mir-660-3p ; hsa-mir-6736-3p ; hsa-mir-6890-3p ; hsa-mir-4714-3p
Nearest miRNA
hsa-mir-4277/Upstream/265633; hsa-mir-10397/Downstream/1082836;
Nearest TSS
ENST00000502646/Upstream/53983; ENST00000511310/Downstream/43747;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/861368, chr5-CpG: 138/Downstream/225052
Upstream sequence
AGTGGAGATCAGTAGAGGACACAGAAAAAAGATAGATTAGTTACACTGGGCTTTGGACTCTAGTGTTGTAGGTTTTAGAAACAACTCATTAACCTACCTC
Downstream sequence
CACGAGGTGGGATCTCCAAGAAGCCAAGGATGCTGTTATAATGGGCTGGTCCAAGGTCACTTCTTATTGGTTTTACAACACCTATAAGACATAAATGTTG
Target sequence
AGTATTCTTTGCTTCAGCCTCTAACTGAAATCCTGGCATCATGTAAATGGGAAGATGGGGCGGGGATGTGCACCAGCAGCACCCCAAAGAGGAAGGGAGGAGAAAGCCAGCCTAAGTGCAAATAATAATGTCAAGAACATGCTGGCACATAATGGTAAGCAAACTCTAAGATGCAAATGAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate