Basic Information
VIS ID
TVIS30016266
Fusion event
HIV-C5orf22 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
31553958/31553851 (Hg38)
End
31553853/31553851 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA5A
Target gene
C5orf22
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-93-5p ; hsa-mir-505-5p ; hsa-mir-193a-3p ; hsa-mir-433-3p ; hsa-mir-193b-3p ; hsa-mir-551b-5p ; hsa-mir-548s ; hsa-mir-3190-5p ; hsa-mir-3926 ; hsa-mir-4461 ; hsa-mir-4463 ; hsa-mir-7154-5p ; hsa-mir-580-3p ; hsa-mir-383-5p ; hsa-mir-539-5p ; hsa-mir-2115-3p ; hsa-mir-1206 ; hsa-mir-6716-5p ; hsa-mir-15b-3p ; hsa-mir-759
Nearest miRNA
hsa-mir-10397/Upstream/14397859; hsa-mir-103a-1/Downstream/382251;
Nearest TSS
ENST00000502646/Upstream/8180; ENST00000513910/Downstream/85559;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/21421, chr5-CpG: 107/Downstream/85095
Upstream sequence
TGGTCTGGTTGAGTAAACTTGACCAAACAAAAATTAACTGTTTTTTGCTTTTCTGTTTTTGTTTTGCTGATCAAAAAAGCCCTTCAGGGTCTCTTGTGCA
Downstream sequence
TCCAGGAGGTCATTGTAGATATCAATAATATAGTGCCTAAGTGCCACTTTATTGCCAAGTCTAGATTGATACTTTTTTCAGATAAACCAGCTTTTTATGT
Target sequence
CAAGGTGGTCTGGTTGAGTAAACTTGACCAAACAAAAATTAACTGTTTTTTGCTTTTCTGTTTTTGTTTTGCTGATCAAAAAAGCCCTTCAGGGTCTCTTGTGCA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate