Basic Information
VIS ID
TVIS30016268
Fusion event
HIV-FYB1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
39167116/39167014 (Hg38)
End
39166969/39167014 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
FYB1
miRNAs that regulate target gene
hsa-mir-4795-3p ; hsa-mir-613 ; hsa-mir-206 ; hsa-mir-1-3p ; hsa-mir-126-5p ; hsa-mir-4307 ; hsa-mir-656-3p ; hsa-mir-33a-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p
Nearest miRNA
hsa-mir-10397/Upstream/609453; hsa-mir-103a-1/Downstream/14784490;
Nearest TSS
ENST00000502646/Upstream/26984; ENST00000603514/Downstream/36013;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/91880, chr5-CpG: 39/Downstream/257776
Upstream sequence
ccatgaaaaaaaacccctgcactttatcccttaaatttatataaataaaaaaaGAAAGGAGGGACCCTGAGTCAAAATATAGCACATAAACATAAGATGA
Downstream sequence
TAAATCAGGTTTTAGAGGAGAGAAAGATATATAaagttggtgcaaaggtaattgcggtttttgccattacttttggtaaaagctgcaattaactttgcac
Target sequence
ggtgatggttataataaaagcccagacttcattactacacacggtatccatgaaaaaaaacccctgcactttatcccttaaatttatataaataaaaaaaGAAAGGAGGGACCCTGAGTCAAAATATAGCACATAAACATAAGATGA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate