Basic Information
VIS ID
TVIS30016277
Fusion event
HIV-PARP8 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
50035002/50739168 (Hg38)
End
50035146/50739168 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
PARP8
miRNAs that regulate target gene
hsa-mir-145-5p
Nearest miRNA
hsa-mir-10397/Upstream/12181607; hsa-mir-103a-1/Downstream/3212336;
Nearest TSS
ENST00000502646/Upstream/71275; ENST00000508923/Downstream/120852;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/71225, chr5-CpG: 53/Downstream/230083
Upstream sequence
GCAAGAGACTTCCCACAGGTATTGAATCAAAGTCCCAAGCTCTACTCTGAATGGAGCACCCTGAACCAACAACCATTGAGGCCAAAGTGTAGGACACAGG
Downstream sequence
GGAATGGATATTGAGGAGGCCTTTGGATGTCCATTACAGATTTATTCTGCTTTTACTCATTCGTTAATTTTTTTTGTGGGGGGATGGGGGTGGGGAGGGA
Target sequence
CTAGGTAACTCCTTTCCTTCCATTGCAGGGGGATCTGTTATCCTGATGGCTTATCCAGTCATTCAGTCTTCCTCTCCACCTGGGAGAAGGGATTCTCCTCATGAAAACCTTAGGGCTTCCATATGAAGAAGGAGAGGAATGAGT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate