Basic Information
VIS ID
TVIS30016283
Fusion event
HIV-PDE4D integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
59447100/60151273 (Hg38)
End
59447021/60151273 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
PDE4D
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-340-5p ; hsa-mir-7-5p ; hsa-mir-103a-3p ; hsa-mir-19b-3p ; hsa-mir-18a-5p ; hsa-mir-16-5p ; hsa-mir-3148 ; hsa-mir-4668-5p ; hsa-mir-4457 ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-6783-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-6835-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-7158-3p ; hsa-mir-548ac ; hsa-mir-31-3p ; hsa-mir-302f ; hsa-mir-4760-3p ; hsa-mir-4282 ; hsa-mir-18b-5p ; hsa-mir-4735-3p ; hsa-mir-4439 ; hsa-mir-3136-5p ; hsa-mir-6857-3p ; hsa-mir-6855-3p ; hsa-mir-4513 ; hsa-mir-4502 ; hsa-mir-4682 ; hsa-mir-1324 ; hsa-mir-4422 ; hsa-mir-3611 ; hsa-mir-4325 ; hsa-mir-4266 ; hsa-mir-642b-3p ; hsa-mir-642a-3p ; hsa-mir-6080 ; hsa-mir-6888-5p ; hsa-mir-3120-3p ; hsa-mir-3646 ; hsa-mir-424-3p ; hsa-mir-199a-5p ; hsa-mir-139-5p
Nearest miRNA
hsa-mir-10397/Upstream/447570; hsa-mir-103a-1/Downstream/12018194;
Nearest TSS
ENST00000502646/Upstream/120387; ENST00000515734/Downstream/111286;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/257592, chr5-CpG: 87/Downstream/548274
Nearby gene
PART1(No orient, 336439)
Upstream sequence
ATAATTAAACATAGAGTAAACAAAAAACTTCATAAATCTCTTTTAGAAGCAACTTTACATTTTGTTCCCAAAAtgatctgcctgcctcagtcttccaaag
Downstream sequence
tgctgggattacaggtgtgagccaccacacttggctaccatttgaattttcataaggattgtattgaatctttgggtagtatggacattttaacagtatt
Target sequence
AAAAAACTTCATAAATCTCTTTTAGAAGCAACTTTACATTTTGTTCCCAAAAtgatctgcctgcctcagtcttccaaag
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate