Basic Information
VIS ID
TVIS30016291
Fusion event
HIV-SERINC5 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
79532851/80237032 (Hg38)
End
79532774/80237032 (Hg38)
Orient
-
Location type
Intronic
Target gene
SERINC5
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-16-5p ; hsa-mir-3926 ; hsa-mir-4753-5p ; hsa-mir-6796-3p ; hsa-mir-4484 ; hsa-mir-6768-3p ; hsa-mir-548an ; hsa-mir-9-5p
Nearest miRNA
hsa-mir-10397/Upstream/7358369; hsa-mir-103a-1/Downstream/2603123;
Nearest TSS
ENST00000502646/Upstream/69852; ENST00000511881/Downstream/18166;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/201367, chr5-CpG: 103/Downstream/18518
Upstream sequence
tccatttcccaggttcaagcgattctcctgcttcaacctcccgccatcatgccgggctaacttttttgtattttgtagagacggggtttcaccacgttgg
Downstream sequence
ccaggccggtctttgaatttctgacctcaggtgatccacccgcctcggcctcccaaagtgctgggattacaggcatgagccactgcgcccggccCCAGTG
Target sequence
tctcctgcttcaacctcccgccatcatgccgggctaacttttttgtattttgtagagacggggtttcaccacgttgg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate