Basic Information
VIS ID
TVIS30016294
Fusion event
HIV-MSH3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
80066395/80770576 (Hg38)
End
80066628/80770576 (Hg38)
Orient
+
Location type
Intronic
Target gene
MSH3
miRNAs that regulate target gene
hsa-mir-326 ; hsa-mir-92b-3p ; hsa-mir-345-5p ; hsa-mir-520g-3p ; hsa-mir-520h ; hsa-mir-4635 ; hsa-mir-3686 ; hsa-mir-3182 ; hsa-mir-4742-3p ; hsa-mir-216b-3p ; hsa-mir-1246 ; hsa-mir-18a-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-150-5p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-1224-3p ; hsa-mir-186-3p ; hsa-mir-3159 ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-4743-3p ; hsa-mir-498 ; hsa-mir-6783-3p ; hsa-mir-6888-3p ; hsa-mir-1343-3p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-3120-5p ; hsa-mir-6787-3p ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-4775 ; hsa-mir-4735-5p ; hsa-mir-6872-3p ; hsa-mir-590-3p ; hsa-mir-3163 ; hsa-mir-145-5p ; hsa-mir-7-5p
Nearest miRNA
hsa-mir-10397/Upstream/7891913; hsa-mir-103a-1/Downstream/2069579;
Nearest TSS
ENST00000502646/Upstream/55371; ENST00000514946/Downstream/182404;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/115522, chr5-CpG: 136/Downstream/189557
Upstream sequence
tatcaagtacttgttaaagtctagaatggtggtaggtgcctacatatattatttaattcttataacaatgcccaaaagggtcattccagtttgttggaaa
Downstream sequence
CGGTCCTGGATTCATTTGGCAGTTTTTGAGTAAAAATGAGAGAAAATTATCAGGAATTCATAAGAGATAGTAGACTGGTTATTCATTATGAGTGTGGCAT
Target sequence
gaaaaccaaggtttggagtagttagataagttacccaaggtccgaagcacaaatccagcccacttctgccagactctaGTCTTTCTATTATATTAATATCAGTATTTCATTCCATTTATTAATTCCAAATATTAACACAAAGATTCTCAACACCATGGATTTTATCTGACAAAATCTAGATATTTTAGAGCTCATAGTATTCAAAATAAAATAAAGTTTAAGTCTTGGAAAGA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate