Basic Information
VIS ID
TVIS30016297
Fusion event
HIV-FAM172A integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q15
Reference genome
GRCh37/hg19
Start
93416284/94080579 (Hg38)
End
93416167/94080579 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5B
Target gene
FAM172A
miRNAs that regulate target gene
hsa-mir-421 ; hsa-mir-330-3p ; hsa-mir-218-5p ; hsa-mir-1827 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-6835-3p
Nearest miRNA
hsa-mir-10397/Upstream/459791; hsa-mir-103a-1/Downstream/1998559;
Nearest TSS
ENST00000502646/Upstream/5808; ENST00000508383/Downstream/31056;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/458945, chr5-CpG: 41/Downstream/30669
Nearest cancer related gene
FAM172A(TSG, No orient, 0)
Upstream sequence
TTAAAATATAATATGCAtgtgaaccatccagatgccccttcaaggagaatgtgctgctcagctagagagtgcagttagcaaacagactccatctgtttat
Downstream sequence
cacttcagagctggcctcaggtgcaaagtgctgcttcatcctaggtcatacctttccactgctgaccctcattcagtgattaagtcaagtggtaatatga
Target sequence
GAGGTTCAACATAGATTTTAAAATATAATATGCAtgtgaaccatccagatgccccttcaaggagaatgtgctgctcagctagagagtgcagttagcaaacagactccatctgtttat
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate