Basic Information
VIS ID
TVIS30016301
Fusion event
HIV-TTC37 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q15
Reference genome
GRCh37/hg19
Start
94877080/95541376 (Hg38)
End
94877114/95541376 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA5B
Target gene
TTC37
miRNAs that regulate target gene
hsa-mir-421 ; hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-186-3p ; hsa-mir-92a-3p ; hsa-mir-127-5p ; hsa-mir-544a ; hsa-mir-377-5p ; hsa-mir-4482-3p ; hsa-mir-5701 ; hsa-mir-582-5p ; hsa-mir-101-3p ; hsa-mir-6892-5p ; hsa-mir-545-5p ; hsa-mir-6504-3p ; hsa-mir-144-3p ; hsa-mir-4475 ; hsa-mir-3922-3p ; hsa-mir-3176 ; hsa-mir-3190-5p ; hsa-mir-641 ; hsa-mir-3617-5p
Nearest miRNA
hsa-mir-10397/Upstream/1920588; hsa-mir-103a-1/Downstream/537762;
Nearest TSS
ENST00000502646/Upstream/576; ENST00000504763/Downstream/530;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/255959, chr5-CpG: 61/Downstream/13327
Upstream sequence
AAAAGAAGTCAGAAAATCATTCACCAACCTCTAGGTGTTTCTTTTCTTGGTAATATAGATCCACAAGTTTCTTGCAGACATCACACCACTTCTGCTTGTC
Downstream sequence
AAGGATTTTGAATCTGATTAATAAAAATAACCAAGGACTTAAAACACTAAAATTTAAGTATTCCAATAATAATTTCAGGTACTATTTTAAATTAGAACAT
Target sequence
AACACTTAGAACAAAACAAAACACACACACACAA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate