Basic Information
VIS ID
TVIS30016302
Fusion event
HIV-CHD1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q15
Reference genome
GRCh37/hg19
Start
98213753/98878049 (Hg38)
End
98213781/98878049 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5F
Target gene
CHD1
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-30b-5p ; hsa-mir-98-5p ; hsa-let-7b-5p ; hsa-mir-130b-5p ; hsa-mir-30c-5p ; hsa-let-7c-5p ; hsa-mir-26a-5p ; hsa-mir-4503 ; hsa-mir-6792-5p ; hsa-mir-3194-5p ; hsa-mir-4691-3p ; hsa-mir-570-3p ; hsa-mir-3613-3p ; hsa-mir-7849-3p ; hsa-mir-8054 ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-548n ; hsa-mir-501-5p ; hsa-mir-4700-3p ; hsa-mir-500b-5p ; hsa-mir-362-5p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-194-5p
Nearest miRNA
hsa-mir-10397/Upstream/2798837; hsa-mir-103a-1/Downstream/1938433;
Nearest TSS
ENST00000502646/Upstream/5492; ENST00000513175/Downstream/8182;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/103446, chr5-CpG: 182/Downstream/49993
Nearest cancer related gene
CHD1(TSG, No orient, 0)
Upstream sequence
cctacacatctaaatgtaaggatatacaggagattacaaaaagagaaaaagaggacttgaacagtggctcatttgtgaagaacacaggtgacagaaatca
Downstream sequence
cagctaaaatctgctaatggctgagtgtacgctattgtgagatcacaggacctaacagccaaaactcggaggacctgcacccactctcaagcactttgcc
Target sequence
agtaccatacaagcaggtaagaggagat
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate