Basic Information
VIS ID
TVIS30016305
Fusion event
HIV-TNFAIP8 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
118684128/119348433 (Hg38)
End
118684205/119348433 (Hg38)
Orient
+
Location type
Intronic
Target gene
TNFAIP8
miRNAs that regulate target gene
hsa-mir-452-5p ; hsa-mir-574-5p ; hsa-mir-23c ; hsa-mir-23b-3p ; hsa-mir-23a-3p ; hsa-mir-130a-5p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-630 ; hsa-mir-4717-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-6769b-5p ; hsa-mir-6769a-5p ; hsa-mir-92a-2-5p ; hsa-mir-654-5p ; hsa-mir-541-3p ; hsa-mir-6787-3p ; hsa-mir-6884-3p ; hsa-mir-3614-3p ; hsa-mir-9-5p ; hsa-mir-193b-5p ; hsa-mir-483-5p
Nearest miRNA
hsa-mir-10397/Upstream/193717; hsa-mir-103a-1/Downstream/9749255;
Nearest TSS
ENST00000502646/Upstream/15258; ENST00000504642/Downstream/5881;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/79294, chr5-CpG: 42/Downstream/7273
Upstream sequence
ATCTCATCACAAAATTATTTCCTTGCCATAAGGAGTAAAGGCAGTGGTTAGAGTGGAAATAATTTGACAATTACTGCCCTTAGACTTGAattttagttta
Downstream sequence
ttgtcaaggcaattctggatgaatgtctgttgccggtgatgtgataggagattgcttcaccagccaggtagaggattaaacaatctctggctgggcacgg
Target sequence
gtatacacaggaactttctaacggttaggatggaaatggagttgttttttcaaggaggctgtctctggtaataaagt
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate