Basic Information
VIS ID
TVIS30016313
Fusion event
HIV-HSPA4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
132391453/133055761 (Hg38)
End
132391387/133055761 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5C
Target gene
HSPA4
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-30c-5p ; hsa-mir-26b-5p ; hsa-mir-942-5p ; hsa-mir-615-3p ; hsa-mir-320a ; hsa-mir-10a-5p ; hsa-mir-148a-3p ; hsa-mir-197-3p ; hsa-mir-6804-5p ; hsa-mir-4710 ; hsa-mir-493-3p ; hsa-mir-6806-3p ; hsa-mir-3928-5p ; hsa-mir-3185 ; hsa-mir-125a-3p ; hsa-mir-6854-5p ; hsa-mir-552-3p ; hsa-mir-6768-5p ; hsa-mir-4517 ; hsa-mir-7856-5p ; hsa-mir-3658 ; hsa-mir-3653-3p ; hsa-mir-5680 ; hsa-mir-4282 ; hsa-mir-2355-5p ; hsa-mir-4286 ; hsa-mir-3613-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-6734-3p ; hsa-mir-302c-5p ; hsa-mir-593-5p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-4742-5p ; hsa-mir-216b-3p ; hsa-mir-200a-3p ; hsa-mir-141-3p ; hsa-let-7c-5p
Nearest miRNA
hsa-mir-10397/Upstream/690162; hsa-mir-103a-1/Downstream/371835;
Nearest TSS
ENST00000502646/Upstream/3520; ENST00000504328/Downstream/20282;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/3084, chr5-CpG: 192/Downstream/555292
Nearest cancer related gene
HSPA4(OG, No orient, 0)
Upstream sequence
catggctggtggattaaaccaaatactaaacaaaaatatgtagtaattactaactgtggtaaagggcaaggtggaaaagtacagaatacagtgagagtat
Downstream sequence
agaataagcgggtctaatttaaattggatggaaggacctggcacgatagctcatgcctgtaatcccagcactctgggaggctgaggtaggaggatcgctt
Target sequence
aatatgtagtaattactaactgtggtaaagggcaaggtggaaaagtacagaatacagtgagagtat
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate