VISDB - VIS Detail

Basic Information

VIS ID

TVIS30016319

Fusion event

HIV-UBE2D2 integration

Validated

Yes

Detection method

LM PCR

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

24968937

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr5

Cytoband

q31.2

Reference genome

GRCh37/hg19

Start

138977164/139597579 (Hg38)

End

138977368/139597579 (Hg38)

Orient

Location type

Intronic

Target gene

UBE2D2

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-let-7b-5p ; hsa-mir-10a-5p ; hsa-mir-30c-5p ; hsa-mir-105-5p ; hsa-mir-130a-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-518a-5p ; hsa-mir-527 ; hsa-mir-559 ; hsa-mir-548b-5p ; hsa-mir-548a-5p ; hsa-mir-548c-5p ; hsa-mir-548d-5p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-548j-5p ; hsa-mir-548h-5p ; hsa-mir-548i ; hsa-mir-548w ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-3668 ; hsa-mir-548y ; hsa-mir-548o-5p ; hsa-mir-548ab ; hsa-mir-548ad-5p ; hsa-mir-548ae-5p ; hsa-mir-548ak ; hsa-mir-548am-5p ; hsa-mir-3973 ; hsa-mir-4671-3p ; hsa-mir-548ap-5p ; hsa-mir-548aq-5p ; hsa-mir-548ar-5p ; hsa-mir-548as-5p ; hsa-mir-548au-5p ; hsa-mir-548ay-5p ; hsa-mir-7853-5p ; hsa-mir-548bb-5p ; hsa-mir-4274 ; hsa-mir-4694-3p ; hsa-mir-3924 ; hsa-mir-4473 ; hsa-mir-7852-3p ; hsa-mir-944 ; hsa-mir-4674 ; hsa-mir-4437 ; hsa-mir-5093 ; hsa-mir-551b-5p ; hsa-mir-376b-3p ; hsa-mir-376a-3p

Nearest miRNA

hsa-mir-10397/Upstream/1949930; hsa-mir-103a-1/Downstream/966092;

Nearest TSS

ENST00000502646/Upstream/35550; ENST00000511691/Downstream/1983;

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/35372, chr5-CpG: 52/Downstream/39899

Upstream sequence

ATGGATCTTGTATTCTGCTTAGATAAATCTTAGCTCTTGAGTTAAAAACCTTGATGTTATTCAGCATGGAAAAAAGTAACTCAGTTTGAAAGGGGCAAAA

Downstream sequence

ATTACTTTTTTTCTTGAGATGGGCAGAAAATCTCTATTTTAGAGACATAAAATCTAAAATTTGAGATATTTGAGTAAGTTAATCGTTATCTCAATCCAGA

Target sequence

GATTAAAGCGAAATCAAAAGTAAAATTCCACTTAATGAACATGGCAGGACTTCAGAATTGTTCAATTGTTAAATTGTTAAATTCAAGTTATATTTTAATTAACAACCTGTTGCTATAGCAATGTCTTAAATAAAGCCAGGTGTTCTTAGTTATACCAACCTGTGCTGTCAGTAATATTTGAGAATGGGAACTATACAGTAGGCT

Reference

Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.