Basic Information
VIS ID
TVIS30016336
Fusion event
HIV-HMMR integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q34
Reference genome
GRCh37/hg19
Start
162896981/163469975 (Hg38)
End
162896825/163469975 (Hg38)
Orient
-
Location type
Intronic
Target gene
HMMR
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-98-5p ; hsa-mir-93-3p ; hsa-mir-106b-5p
Nearest miRNA
hsa-mir-10397/Upstream/2984525; hsa-mir-103a-1/Downstream/4695870;
Nearest TSS
ENST00000502646/Upstream/9315; ENST00000519719/Downstream/24059;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/9739, chr5-CpG: 58/Downstream/35473
Upstream sequence
CGTTTTTTAGggccgggcacggtggctcacgcctgtgttcccagcattttgggaggccaaggcaggcggatcacctgaggtcgggagttcgagaccagcc
Downstream sequence
tgaccaacatggagaaaccctgtctctactaaaaatacaaaaattagctaggcctattggcgggcgcctgtaatctcagctactcgggaggctgaggcag
Target sequence
AAAATCTAAGGTATCTGAGCCTCATGATAATATTTACAATTGAATAAATATAAACACGTTTTTTAGggccgggcacggtggctcacgcctgtgttcccagcattttgggaggccaaggcaggcggatcacctgaggtcgggagttcgagaccagcc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate