Basic Information
VIS ID
TVIS30016338
Fusion event
HIV-STK10 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
171496450/172069446 (Hg38)
End
171496529/172069446 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
STK10
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-1225-3p ; hsa-mir-1233-3p ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-214-3p ; hsa-mir-302c-3p ; hsa-mir-3617-3p ; hsa-mir-3619-5p ; hsa-mir-365a-5p ; hsa-mir-365b-5p ; hsa-mir-3940-3p ; hsa-mir-4291 ; hsa-mir-4519 ; hsa-mir-4652-5p ; hsa-mir-520f-3p ; hsa-mir-6512-3p ; hsa-mir-6720-5p ; hsa-mir-6849-3p ; hsa-mir-761 ; hsa-mir-922
Nearest miRNA
hsa-mir-10397/Upstream/682686; hsa-mir-10523/Downstream/592719;
Nearest TSS
ENST00000502646/Upstream/5846; ENST00000398186/Downstream/12959;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/13673, chr5-CpG: 162/Downstream/117980
Nearest cancer related gene
STK10(TSG, No orient, 0)
Upstream sequence
atactgtatgcaaacacttatcaaaagaaagtaggattggctatttattagacaaggtagacttcagaacaaggaatattatcaggaataatgatgggca
Downstream sequence
ggaggatcacttgagcccaggagtttgagggcactctgggcaacatagttagacttccattgcaaagaaaataaacaaataaataaataaaagaaaatgt
Target sequence
ttatataattataaaaggaagactcagttcactaagaaaatatgactattttagtcttagctaaagtctaggaggctga
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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