Basic Information
VIS ID
TVIS30016352
Fusion event
HIV-EXOC2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
618335/618335 (Hg38)
End
618526/618335 (Hg38)
Orient
+
Location type
Intronic
Target gene
EXOC2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-615-3p ; hsa-mir-30d-5p ; hsa-mir-30a-5p ; hsa-mir-570-3p ; hsa-mir-5582-3p ; hsa-mir-548as-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-659-3p ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-563 ; hsa-mir-380-5p ; hsa-mir-203a-3p ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-1252-3p
Nearest miRNA
hsa-mir-10398/Downstream/771979;
Nearest TSS
ENST00000381078/Upstream/94164; ENST00000607644/Downstream/38628;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/80813, chr6-CpG: 76/Downstream/38074
Upstream sequence
TTGTACATTCACTGAAGCATTGTGGAACACTAAGCATAATGTTATACTTATCAGTATCCAGTCCTCTGTCCTTAGTCATAAAATTACATGAATCCTGTGG
Downstream sequence
ATAATAGAAATTCTACATCTGTAATGTAAAATCAGAATCATCTTCTACAATGAAAAAATTCATCTTGGACATTTGCTTTAAAAAGCAATCAGGTTAAATT
Target sequence
GTCGATTCACAACTTAAATAACTAGGAAGACCACAATATCTCATCTCAATATCTAAAGCAGAGAAAACTAAAGACAGGCCTCTGTATTTCAGAAGTTTTATGTCCATTTGAGCTAAGAAAATCCGGCTATAAAACTTTAAACGTATTCTTGATAGACCTACACAAGAAACAGAGCTCAATTCTGACTTATA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate