Basic Information
VIS ID
TVIS30016358
Fusion event
HIV-HIVEP1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
12097612/12097379 (Hg38)
End
12097523/12097379 (Hg38)
Orient
-
Location type
Intronic
Target gene
HIVEP1
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-98-5p ; hsa-mir-32-5p ; hsa-mir-23a-3p ; hsa-mir-363-3p ; hsa-mir-25-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-433-3p ; hsa-mir-92b-3p ; hsa-mir-1206 ; hsa-mir-7154-5p ; hsa-mir-595 ; hsa-mir-410-3p ; hsa-mir-3613-3p ; hsa-mir-190a-3p ; hsa-mir-3163 ; hsa-mir-548e-5p
Nearest miRNA
hsa-mir-3691/Upstream/1657585; hsa-mir-10398/Downstream/4044177;
Nearest TSS
ENST00000381078/Upstream/81792; ENST00000399469/Downstream/28367;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/84545, chr6-CpG: 44/Downstream/652266
Nearest cancer related gene
HIVEP1(TSG, No orient, 0)
Upstream sequence
TAATTTATTTAGTAAATTGTTGTTGTGCACCAGCCATTTTTTTTTTTTTTTGCCCTGAGAAATAGATAGGAAAGAAAAAGTCTAAACCTTAAAGGAGCCC
Downstream sequence
GCAAGCTTTAACCCAGCTCTTACCCAAATCATCATAAATCCTGAATTGGTAGAGCAAAAATTCATGAGGTAGACTGGCAGCAGTGCCTAACAAATTTCCC
Target sequence
GTAAATTGTTGTTGTGCACCAGCCATTTTTTTTTTTTTTTGCCCTGAGAAATAGATAGGAAAGAAAAAGTCTAAACCTTAAAGGAGCCC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate