Basic Information
VIS ID
TVIS30016368
Fusion event
HIV-CARMIL1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
25456567/25456339 (Hg38)
End
25456656/25456339 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6C
Target gene
CARMIL1
miRNAs that regulate target gene
hsa-mir-149-5p
Nearest miRNA
hsa-mir-3691/Upstream/6884459; hsa-mir-10398/Downstream/1691287;
Nearest TSS
ENST00000381078/Upstream/176911; ENST00000497227/Downstream/9197;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/176677, chr6-CpG: 21/Downstream/195891
Upstream sequence
GATCTATATAGGTGCTTCATGGTAATTTGTAAGCAATTTGAATGTTGTGATAATGTTTTCTTATTTATTTACTATGGTTCTATCAGAACTGAATCTAGGA
Downstream sequence
TAATTAGGAAGTACTTGGAAAAATGCCCACTCCAGTTGTTATTTGTAAAATGTCCAGTTGGCATTTTATTTAAGTATATTCTTTCAATTTGTTCTGTTTT
Target sequence
CCAGTCCCTCTGTTGTTGCTGAATAAGCATTCAGGAATAAGGATGACAGTGATCATGCTAGATCTAGCCAGTTAGTCTCTGGAGAACAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate