Basic Information
VIS ID
TVIS30016369
Fusion event
HIV-TRIM38 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
25980295/25980067 (Hg38)
End
25980334/25980067 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6C
Target gene
TRIM38
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-21-5p ; hsa-mir-1273e ; hsa-mir-448 ; hsa-mir-489-3p ; hsa-mir-3913-3p ; hsa-mir-586 ; hsa-mir-29b-2-5p ; hsa-mir-6079 ; hsa-mir-876-3p ; hsa-mir-323a-5p ; hsa-mir-6077 ; hsa-mir-600 ; hsa-mir-4705 ; hsa-mir-34b-3p ; hsa-mir-6765-5p ; hsa-mir-1304-5p ; hsa-mir-4775 ; hsa-mir-502-5p ; hsa-mir-1827 ; hsa-mir-129-5p ; hsa-mir-3194-3p ; hsa-mir-3607-3p ; hsa-mir-3672 ; hsa-mir-3686 ; hsa-mir-431-5p ; hsa-mir-4524a-3p ; hsa-mir-4633-3p ; hsa-mir-5691 ; hsa-mir-624-3p ; hsa-mir-6500-5p ; hsa-mir-6805-3p ; hsa-mir-6864-3p ; hsa-mir-6874-5p ; hsa-mir-8055
Nearest miRNA
hsa-mir-3691/Upstream/7408187; hsa-mir-10398/Downstream/1167559;
Nearest TSS
ENST00000381078/Upstream/17265; ENST00000606723/Downstream/12595;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/97735, chr6-CpG: 63/Downstream/11886
Upstream sequence
tcatctttttattattggtttataatcttatattgaggctagagaaaatgatctgtgtaatacagatttattgaaacttgttcagactgttttctgccta
Downstream sequence
aaaactgcatattctctgcttactattattaaacaattgctgagctttatgtattgactatgagattgcgcttcttagattgttcagaccttccgtatct
Target sequence
gtatttactcagttagtgcatgttccatctatacctgag
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate