Basic Information
VIS ID
TVIS30016387
Fusion event
HIV-PPP1R10 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.33
Reference genome
GRCh37/hg19
Start
30579734/30611957 (Hg38)
End
30579691/30611957 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
PPP1R10
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-335-5p ; hsa-mir-30a-5p ; hsa-mir-1914-3p ; hsa-mir-615-3p ; hsa-mir-324-3p ; hsa-let-7e-5p ; hsa-mir-383-5p ; hsa-mir-4291 ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-4769-5p ; hsa-mir-4654 ; hsa-mir-194-3p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-5195-5p ; hsa-mir-338-5p ; hsa-mir-592 ; hsa-mir-6796-5p ; hsa-mir-6810-5p ; hsa-mir-4666b ; hsa-mir-597-5p ; hsa-mir-6742-5p ; hsa-mir-4472 ; hsa-mir-4447 ; hsa-mir-3151-5p ; hsa-mir-491-5p ; hsa-mir-4652-5p ; hsa-mir-3191-3p ; hsa-mir-3144-5p ; hsa-mir-1914-5p ; hsa-mir-759 ; hsa-mir-299-3p ; hsa-mir-6874-3p ; hsa-mir-148b-5p ; hsa-mir-3154
Nearest miRNA
hsa-mir-3143/Upstream/27540; hsa-mir-10398/Downstream/278926;
Nearest TSS
ENST00000381078/Upstream/5220; ENST00000492316/Downstream/5287;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/40247, chr6-CpG: 57/Downstream/5151
Nearest cancer related gene
PPP1R10(OG, No orient, 0)
Upstream sequence
AAAAGATTAGATGTCCGTGGGCCAAATCCACTCAAGTGTGGTGATTCCTACACACACAGAGACAGACACAGAAATAAAGGTATTCTTCCCATGTAGTGAG
Downstream sequence
ATACTATAAAGTGATCTATAGAAACTATAAAGAGATACGATAAAGGGACACATAAAACAGATATCACATCTGTTGGAGACTGGAAAAGCAATGTATGGGT
Target sequence
AGAGACAGACACAGAAATAAAGGTATTCTTCCCATGTAGTGAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate