Basic Information
VIS ID
TVIS30016390
Fusion event
HIV-TCF19 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.33
Reference genome
GRCh37/hg19
Start
31131661/31163884 (Hg38)
End
31131456/31163884 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA6H
Target gene
TCF19
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-107 ; hsa-mir-10b-5p
Nearest miRNA
hsa-mir-3143/Upstream/272912; hsa-mir-10398/Downstream/191340;
Nearest TSS
ENST00000381078/Upstream/2400; ENST00000414008/Downstream/2058;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/5100, chr6-CpG: 19/Downstream/16708
Upstream sequence
TGCCACACCCGCCCTTTCCTACCTAGATTTAATGAGCCCAAGTTTTTAAAATGGAAGAAATGACTCTGGGGCAAAGACCCCTAATGAACTAGTGGCAGAG
Downstream sequence
CCAGGAATAAAACTTGAGTAACTAATGAGTCACTTATGGGCAGAGTATGCAAAAACCTTAAGTGGAAACCAAATAGACCCTGGTATCAAGAAAGCACAAA
Target sequence
TGGTACATGTGATTTTCTTTTGTGAGCCTTACACCAAGCCAAACTATTGTCAAAGCATCATTTCTATAGAAATAAAGCCTTATCTTGACCTGTTCTATTAAAACCTGCCACACCCGCCCTTTCCTACCTAGATTTAATGAGCCCAAGTTTTTAAAATGGAAGAAATGACTCTGGGGCAAAGACCCCTAATGAACTAGTGGCAGAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate