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Viral Integration Site DataBase
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TVIS30016407
Basic Information
VIS ID
TVIS30016407
Fusion event
HIV-FKBP5 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
35567456/35599679 (Hg38)
End
35567311/35599679 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
FKBP5
miRNAs that regulate target gene
hsa-mir-21-5p
;
hsa-mir-93-3p
;
hsa-mir-328-3p
;
hsa-mir-22-3p
;
hsa-mir-100-5p
;
hsa-mir-99a-5p
;
hsa-mir-6516-5p
;
hsa-mir-550b-2-5p
;
hsa-mir-4443
;
hsa-mir-455-3p
;
hsa-mir-650
;
hsa-mir-3612
;
hsa-mir-6499-3p
;
hsa-mir-2467-3p
;
hsa-mir-6086
;
hsa-mir-377-5p
;
hsa-mir-1827
;
hsa-mir-4537
;
hsa-mir-5186
;
hsa-mir-4257
;
hsa-mir-6511a-5p
;
hsa-mir-1910-3p
;
hsa-mir-1243
;
hsa-mir-3654
;
hsa-mir-429
;
hsa-mir-200c-3p
;
hsa-mir-200b-3p
;
hsa-mir-302c-5p
;
hsa-mir-7106-5p
;
hsa-mir-6878-5p
;
hsa-mir-6797-5p
;
hsa-mir-1249-5p
;
hsa-mir-6133
;
hsa-mir-765
;
hsa-mir-6130
;
hsa-mir-6129
;
hsa-mir-6127
;
hsa-mir-4510
;
hsa-mir-4419a
;
hsa-mir-539-5p
;
hsa-mir-6754-5p
;
hsa-mir-4441
;
hsa-mir-4270
;
hsa-mir-4756-5p
;
hsa-mir-4739
;
hsa-mir-1321
;
hsa-mir-4779
;
hsa-mir-6760-5p
;
hsa-mir-7977
;
hsa-mir-3166
;
hsa-mir-3664-3p
;
hsa-mir-5690
;
hsa-mir-510-5p
;
hsa-mir-512-5p
;
hsa-mir-4666a-5p
;
hsa-mir-4740-5p
;
hsa-mir-4272
;
hsa-mir-6816-3p
;
hsa-mir-3169
;
hsa-mir-8080
;
hsa-mir-6783-3p
;
hsa-mir-1343-3p
;
hsa-mir-23b-5p
;
hsa-mir-23a-5p
;
hsa-mir-6829-3p
;
hsa-mir-6791-3p
;
hsa-mir-1281
;
hsa-mir-6742-3p
;
hsa-mir-6852-5p
;
hsa-mir-939-3p
;
hsa-mir-660-3p
;
hsa-mir-4485-5p
;
hsa-mir-511-5p
;
hsa-mir-28-5p
;
hsa-mir-3139
;
hsa-mir-3190-5p
;
hsa-mir-3613-3p
;
hsa-mir-3675-3p
;
hsa-mir-3926
;
hsa-mir-4684-5p
;
hsa-mir-4786-5p
;
hsa-mir-548c-3p
;
hsa-mir-548s
;
hsa-mir-5589-5p
;
hsa-mir-6771-3p
;
hsa-mir-6776-5p
;
hsa-mir-6849-3p
;
hsa-mir-708-5p
Nearest miRNA
hsa-mir-1236/Upstream/129100; hsa-mir-10398/Downstream/65038;
Nearest TSS
ENST00000381078/Upstream/55047;
ENST00000471400/Downstream/89236;
Nearest CpG islands
None/Target,
chr6-CpG: 120/Upstream/87302
,
chr6-CpG: 165/Downstream/88151
Upstream sequence
TAATACCATCTTGATGTGTTCCCCTTGCAGACACAGAATGGGGTCTAAGAAACTTGGGCCAAACTAGAAAGGGCCTAACTCTTGAGTCAGCTCCTCCAAA
Downstream sequence
CAAGGGCTAGAGTTGGAGTGGCTTGGTAGAGCTCGCATATGGCATTTTAGTTTATGTCCCACACTCATAAATGCTGATAATTCCTTCTGTTAGACTTACT
Target sequence
gctgccgaagtgagtacTCACTACTCTTTTTTAACTCACCAGTATTAATACCATCTTGATGTGTTCCCCTTGCAGACACAGAATGGGGTCTAAGAAACTTGGGCCAAACTAGAAAGGGCCTAACTCTTGAGTCAGCTCCTCCAAA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT1
Sample type
PBMC
Age
47
Gender
Male
CpG Island Information
×
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