Basic Information
VIS ID
TVIS30016413
Fusion event
HIV-C6orf89 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
36851291/36883515 (Hg38)
End
36851149/36883515 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
C6orf89
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-3918 ; hsa-mir-4685-5p ; hsa-mir-6837-5p ; hsa-mir-6895-5p ; hsa-mir-7106-3p ; hsa-mir-6741-5p ; hsa-mir-4662a-5p ; hsa-mir-5580-5p ; hsa-mir-6868-5p ; hsa-mir-1245b-3p ; hsa-mir-5096 ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-6802-3p ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-193b-5p ; hsa-mir-1273f ; hsa-mir-3620-3p ; hsa-mir-6865-3p ; hsa-mir-6890-5p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-7113-5p
Nearest miRNA
hsa-mir-1236/Upstream/261003; hsa-mir-10398/Downstream/671850;
Nearest TSS
ENST00000381078/Upstream/8491; ENST00000355190/Downstream/2339;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/8446, chr6-CpG: 36/Downstream/2299
Nearby gene
C6orf89(No orient, 2348)
Upstream sequence
aagatcatagatcaaaacttctactatcacaagactcttatctttgaatattttttccttgtttatgcctctatgaacaatagaaattaaaagtgggtct
Downstream sequence
attatatgcacttatagggtatacttttatttgtgaaggattttgcagccagccttaaacatgaataaccttatatttcaatagataaaagatgaaggcc
Target sequence
tctccccagaagatggcatccttgattagaatagcttttcccaagatcatagatcaaaacttctactatcacaagactcttatctttgaatattttttccttgtttatgcctctatgaacaatagaaattaaaagtgggtct
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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