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TVIS30016419
Basic Information
VIS ID
TVIS30016419
Fusion event
HIV-BTBD9 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
38543425/38575649 (Hg38)
End
38543289/38575649 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
BTBD9
miRNAs that regulate target gene
hsa-mir-335-5p
;
hsa-mir-30e-5p
;
hsa-mir-149-5p
;
hsa-mir-26a-5p
;
hsa-let-7b-5p
;
hsa-mir-548t-5p
;
hsa-mir-548az-5p
;
hsa-mir-5692a
;
hsa-mir-574-5p
;
hsa-mir-6818-5p
;
hsa-mir-6867-5p
;
hsa-mir-6731-5p
;
hsa-mir-8085
;
hsa-mir-4644
;
hsa-mir-4306
;
hsa-mir-185-5p
;
hsa-mir-6133
;
hsa-mir-6130
;
hsa-mir-6127
;
hsa-mir-6129
;
hsa-mir-4510
;
hsa-mir-4419a
;
hsa-mir-6760-5p
;
hsa-mir-6873-5p
;
hsa-mir-4719
;
hsa-mir-1178-3p
;
hsa-mir-369-3p
;
hsa-mir-6792-3p
;
hsa-mir-4691-5p
;
hsa-mir-6781-5p
;
hsa-mir-4268
;
hsa-mir-4660
;
hsa-mir-766-3p
;
hsa-mir-7112-5p
;
hsa-mir-338-3p
;
hsa-mir-4530
;
hsa-mir-3918
;
hsa-mir-6736-3p
;
hsa-mir-3065-3p
;
hsa-mir-6871-3p
;
hsa-mir-6749-3p
;
hsa-mir-7151-3p
;
hsa-mir-5095
;
hsa-mir-6829-3p
;
hsa-mir-6791-3p
;
hsa-mir-600
;
hsa-mir-2116-3p
;
hsa-mir-5193
;
hsa-mir-4700-3p
;
hsa-mir-374c-5p
;
hsa-mir-4643
;
hsa-mir-466
;
hsa-mir-4789-3p
;
hsa-mir-655-3p
Nearest miRNA
hsa-mir-1236/Upstream/1020227; hsa-mir-10398/Downstream/498665;
Nearest TSS
ENST00000381078/Upstream/93957;
ENST00000373278/Downstream/18686;
Nearest CpG islands
None/Target,
chr6-CpG: 120/Upstream/755875
,
chr6-CpG: 77/Downstream/63780
Upstream sequence
ACAATGAATAATTGTGAAGATAAGAAACACCAAGACATCCTCAGTTAATCTACAGAGACATATTCTTAGGTTCATTTTTAAATACTATCAAAATTATAAC
Downstream sequence
CTAGTAAAAAAGACAGTTTACTAAGGAAAGTAGTAATATAATAAAGTGGCTATAATTTTTAAAAAATTCTTATTAACATGGATATCAAGATTCTTTCCTT
Target sequence
CTTGGAAGAAGTGCAGTTAGAACATTGTTTAGGTAGACAATGAATAATTGTGAAGATAAGAAACACCAAGACATCCTCAGTTAATCTACAGAGACATATTCTTAGGTTCATTTTTAAATACTATCAAAATTATAAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT1
Sample type
PBMC
Age
47
Gender
Male
CpG Island Information
×
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