Basic Information
VIS ID
TVIS30016423
Fusion event
HIV-chr6 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
43002398/43034660 (Hg38)
End
43002066/43034660 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA6H
Nearest miRNA
hsa-mir-10398/Upstream/1301050; hsa-mir-10524/Downstream/399882;
Nearest TSS
ENST00000381078/Upstream/255; ENST00000472792/Downstream/6117;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/12888, chr6-CpG: 50/Downstream/18727
Nearby gene
CUL7(No orient, 2956)
Nearest cancer related gene
CUL7(OG, No orient, 2956)
Upstream sequence
GTGTTCTTCCCTTAAGAATTGCTGTAggctaggtgaggtggctcacacctgtaatcccagcactttgggaggctgaggtgggcggatcacctgaggtcgg
Downstream sequence
gagttcgaaaccagcctgaccaacatggagcaaccctgtctctactaaaaatacaaaattagccgggtgtggtggcgcatgcctgtaatcccagctactc
Target sequence
GAGGCCAACTCTCTGCCCTCTAGAATGGATGGCCCTGAGGGAGAGAAAGGTTCATGTCCTTCCTGGCTGGTGACAGAAGGCTGGACTGTGCCTGAAATCAAAGCTTCTCACCTGGATTTGGGCAAATCAAGCAGTCCCGAATCTCAGGGTGGGGTGAGATGTGTGCTGAAGAGGGCAACACAGGAGCTGCACTGCAGATGGCGACATGCAGGGTTTCAAGGCCAAAGCTGGTGTGTTCTTCCCTTAAGAATTGCT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate