VISDB - VIS Detail

Basic Information

VIS ID

TVIS30016449

Fusion event

HIV-BACH2 integration

Validated

Yes

Detection method

LM PCR

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

24968937

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr6

Cytoband

q15

Reference genome

GRCh37/hg19

Start

90783866/90074147 (Hg38)

End

90784175/90074147 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA6G

Target gene

BACH2

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-29c-3p ; hsa-mir-615-3p ; hsa-mir-8064 ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-6083 ; hsa-mir-5011-5p ; hsa-mir-656-3p ; hsa-mir-410-3p ; hsa-mir-3942-3p ; hsa-mir-1324 ; hsa-mir-8485 ; hsa-mir-6797-3p ; hsa-mir-6076 ; hsa-mir-6807-3p ; hsa-mir-217 ; hsa-mir-509-5p ; hsa-mir-509-3-5p ; hsa-mir-4418 ; hsa-mir-6749-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-2355-5p ; hsa-mir-15b-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-6832-3p ; hsa-mir-620 ; hsa-mir-1270 ; hsa-mir-4531 ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-5695 ; hsa-mir-3145-5p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-4791 ; hsa-mir-3201 ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-5583-3p ; hsa-mir-4517 ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-142-5p

Nearest miRNA

hsa-mir-10398/Upstream/11534838; hsa-mir-1202/Downstream/238595;

Nearest TSS

ENST00000381078/Upstream/65320; ENST00000569865/Downstream/144098;

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/186213, chr6-CpG: 227/Downstream/220929

Upstream sequence

TTTGTATAAATGAATGCATTTAAGCTTTCCTTAGAACAGAAATTGCTTTAATGTTATAGTGAGACAAGTGATTTTCTTTTCTTTTTTAAAAGGGTAGTTT

Downstream sequence

ACACCATAATGATAATGTAAGTGAAGTGCTCACATTAAGGGGTTGACTTCTGACAAGTCAAGGTCTACAGAAAAGTTTCCGCTACAGCAGACATTATGGT

Target sequence

ATAAGTTAATGGTTTTTTGAAGCCCATGTAAAAACTGCCTTCCACAAGACAGAGAACTTCACAATGTTTGTGGTGCATATTTTGCCACATTTCACAAGAGGTCTTATTGTTTAAATTCTTATAGCCTTATGTCATATGTGAACAAATGACTTTATTGTTCATTTGAACATGTCTTTATAGGATCTCTGGTGGTAGAGCTAGTGTTGTTGTTTGCATTTTTCCCCTCAACAAGCCAGAACAAAAGTCTCTTTTACT

Reference

Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.