Basic Information
VIS ID
TVIS30016457
Fusion event
HIV-FBXL4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q16.2
Reference genome
GRCh37/hg19
Start
99369201/98921325 (Hg38)
End
99369277/98921325 (Hg38)
Orient
+
Location type
Intronic
Target gene
FBXL4
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-4439 ; hsa-mir-3136-5p ; hsa-mir-573 ; hsa-mir-3616-5p ; hsa-mir-4474-5p ; hsa-mir-5189-3p ; hsa-mir-6857-3p ; hsa-mir-6855-3p ; hsa-mir-4513 ; hsa-mir-4795-5p
Nearest miRNA
hsa-mir-10398/Upstream/896704; hsa-mir-1202/Downstream/203284;
Nearest TSS
ENST00000381078/Upstream/86733; ENST00000418945/Downstream/26601;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/72747, chr6-CpG: 85/Downstream/26101
Upstream sequence
TTATACCACTAAGAAACTTTCTCCAGGGCAACCAGGAAGCAGTGGGTAGATGAGAGGAAGAGAGATGTTTCATTAATGGAAACCAAAGAAAGCAAGTTTT
Downstream sequence
TAAGTATATCTAGTAGCCAGCAAAGAAAGTTATCTTGCCAACCCTGTTCCATTTCACTAGCTGAAAGTGAAGGAATAATAGGAAAACAGAAATAAAAGTA
Target sequence
CTAACCTGTATTCAGGCTTGAAGCCAGGCAGATGAGTACAAAAAGCTTCCTTGCAACCAAAATTTATCCTAGCCAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate