Basic Information
VIS ID
TVIS30016458
Fusion event
HIV-ASCC3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q16.3
Reference genome
GRCh37/hg19
Start
101249946/100802070 (Hg38)
End
101250076/100802070 (Hg38)
Orient
+
Location type
Intronic
Target gene
ASCC3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-98-5p ; hsa-mir-30a-5p ; hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-1226-3p ; hsa-mir-425-5p ; hsa-let-7f-5p ; hsa-let-7a-5p
Nearest miRNA
hsa-mir-10398/Upstream/1677374; hsa-mir-1202/Downstream/5982055;
Nearest TSS
ENST00000381078/Upstream/291762; ENST00000565695/Downstream/79231;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/332423, chr6-CpG: 68/Downstream/78801
Upstream sequence
ATGCTAAAGTCATTAACATTTTAAGCAAATGTGACAGTAATAAAATATTATACATACTTATGATCATCCAAATAAAATTAAAATTATAAGAAGAAAATAT
Downstream sequence
GGGTTAGGTTAACTGTAGAAACTGACATGCAAAAATGAAATGAATATCCTTAACAGTAATTCTAACACAAAGTTATTCTGAAGAACTATGTAGAGGCTTG
Target sequence
GTCTACCTCATAGAAAGCTTAAAAGGTCTAATTAGAACATACTGGAATCCTGTAAGGCTGAGTATAACAGGCAATTTCAAAAAATCAAGTTGTAAAGCAGTGAATGTTTAAATGTATGGTTCTCCTTGCT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate