Basic Information
VIS ID
TVIS30016462
Fusion event
HIV-MCM9 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
119176174/118855011 (Hg38)
End
119176434/118855011 (Hg38)
Orient
+
Location type
Intronic
Target gene
MCM9
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-203a-3p ; hsa-mir-5579-3p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-3613-3p ; hsa-mir-4538 ; hsa-mir-4453 ; hsa-mir-888-5p ; hsa-mir-6750-3p ; hsa-mir-2909 ; hsa-mir-1296-5p ; hsa-mir-6781-5p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-6499-5p ; hsa-mir-5693 ; hsa-mir-4512 ; hsa-mir-7160-3p ; hsa-mir-6895-5p ; hsa-mir-1273e ; hsa-mir-1827 ; hsa-mir-2467-3p ; hsa-mir-3160-3p ; hsa-mir-34b-3p ; hsa-mir-3614-5p ; hsa-mir-3664-3p ; hsa-mir-377-5p ; hsa-mir-4257 ; hsa-mir-4487 ; hsa-mir-455-3p ; hsa-mir-4695-5p ; hsa-mir-4722-5p ; hsa-mir-4768-3p ; hsa-mir-510-5p ; hsa-mir-512-5p ; hsa-mir-5186 ; hsa-mir-558 ; hsa-mir-6086 ; hsa-mir-6499-3p ; hsa-mir-6500-3p ; hsa-mir-6516-5p ; hsa-mir-6808-5p ; hsa-mir-6828-5p ; hsa-mir-6840-3p ; hsa-mir-6893-5p ; hsa-mir-935 ; hsa-mir-940
Nearest miRNA
hsa-mir-10398/Upstream/12070791; hsa-mir-1202/Downstream/214036;
Nearest TSS
ENST00000381078/Upstream/25758; ENST00000511766/Downstream/39209;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/203037, chr6-CpG: 123/Downstream/39279
Nearest cancer related gene
MCM9(TSG, No orient, 0)
Upstream sequence
tgtcattgctttttcatttcacatttttaataattattttttcttgtattttataacaatatttctcagtgatggagtaaaaaataagtcaaaaccagtc
Downstream sequence
tatattttcttataacacttctattgtggacttatcgctttgctgtcatttttatctatcttttctaataaaaccgtgaatacctgaaggacaatgttct
Target sequence
ctttaccacatagagtggaaaaagcattTTTCCAGTGCACAAAGTAGCTGTGGTTATGACAAACTGCCTGGCCTTTTGGTGCAATAACTGAACAGAATCAGCTACAGAATGCTGATTTTGGAACTTACAACATACTTACAGATAGCACAAAAAGCTCATTAAATGGAGATATAATGAGAAAAGAAACCAGCCTCTGAAGACACTTAATAAACTATACTTCTGATTTCCTCAATCAAAGAGTTTAGAAGCAATAAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate