Basic Information
VIS ID
TVIS30016464
Fusion event
HIV-NCOA7 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q22.32
Reference genome
GRCh37/hg19
Start
126222556/125901410 (Hg38)
End
126222705/125901410 (Hg38)
Orient
+
Location type
Intronic
Target gene
NCOA7
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-5680 ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-32-3p ; hsa-mir-543 ; hsa-mir-1976 ; hsa-mir-2115-5p ; hsa-mir-3653-5p ; hsa-mir-4279 ; hsa-mir-4722-3p ; hsa-mir-498 ; hsa-mir-516a-3p ; hsa-mir-516b-3p ; hsa-mir-5571-5p ; hsa-mir-6727-3p ; hsa-mir-6728-3p ; hsa-mir-6747-3p ; hsa-mir-6778-3p ; hsa-mir-7162-5p
Nearest miRNA
hsa-mir-10398/Upstream/5886153; hsa-mir-1202/Downstream/583221;
Nearest TSS
ENST00000381078/Upstream/1501; ENST00000438495/Downstream/17814;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/110076, chr6-CpG: 72/Downstream/55236
Upstream sequence
CCCAGTTCCTTTTCCTACCAGTCATGCAGCTTTTGATAGGGCAATAATTCCTTAACTGTTCTGGGTTATTTTGAGTACGTTTGTTGGTTTACAACAATGT
Downstream sequence
gcaccagtgggaatgaaccctgtaccagcccatagtagcgtctaggggttgcccacgaccactggagccccagaggtcataggttacaaacagtgctctt
Target sequence
AAATGGCAAtgagatgagagagttcccttgacccctttgtgggacttgcaacagggatatcacctttactcagctgctgcactgaaaccccttgcaggagggggagcacgcaggtgagtgggtacaggagctggggcgggtgcctttgg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate