Basic Information
VIS ID
TVIS30016465
Fusion event
HIV-ARHGAP18 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q22.33
Reference genome
GRCh37/hg19
Start
129952125/129630980 (Hg38)
End
129952168/129630980 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARHGAP18
miRNAs that regulate target gene
hsa-mir-6818-3p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-4725-5p ; hsa-mir-4696 ; hsa-mir-570-3p ; hsa-mir-5699-3p ; hsa-mir-520f-5p ; hsa-mir-4421 ; hsa-mir-6501-3p ; hsa-mir-339-5p ; hsa-mir-451b ; hsa-mir-10b-5p ; hsa-mir-3667-5p ; hsa-mir-10a-5p ; hsa-mir-4282 ; hsa-mir-6759-5p ; hsa-mir-6796-5p ; hsa-mir-4322 ; hsa-mir-4296 ; hsa-mir-4265 ; hsa-mir-4439 ; hsa-mir-3136-5p ; hsa-mir-4769-5p ; hsa-mir-4654 ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-4648 ; hsa-mir-3118 ; hsa-mir-134-5p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-6857-3p ; hsa-mir-6855-3p ; hsa-mir-4513 ; hsa-mir-15b-3p ; hsa-mir-581 ; hsa-mir-5187-3p ; hsa-mir-2681-3p ; hsa-mir-6848-5p ; hsa-mir-6846-5p ; hsa-mir-4697-5p ; hsa-mir-4488 ; hsa-mir-1237-5p ; hsa-mir-486-3p
Nearest miRNA
hsa-mir-10398/Upstream/3146267; hsa-mir-1202/Downstream/2161192;
Nearest TSS
ENST00000381078/Upstream/32019; ENST00000526087/Downstream/79245;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/700806, chr6-CpG: 208/Downstream/388061
Upstream sequence
GTTAAGAAAGTAAGAATTTACCTGTGCCAATTCCAAAACTAAGAATACATTTAAAGCCCGTTGATATTATTAGTATTCATCTGCTGCCATGTATATTTAT
Downstream sequence
TACCTTTTGATGATTAATTTTTTAAAGTATCAACATGAATATCAAAGCACAACTTTAATTTTATTTTCCCTCTGGTTTATTCTCTTTTATGTTTTACTGT
Target sequence
GTTTCTCAACAGCCTGTGACCATTTTTTAAATTAGAATACCTA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate