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VISDB
Viral Integration Site DataBase
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TVIS30016468
Basic Information
VIS ID
TVIS30016468
Fusion event
HIV-HBS1L integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
135365969/135044831 (Hg38)
End
135366186/135044831 (Hg38)
Orient
+
Location type
Intronic
Target gene
HBS1L
miRNAs that regulate target gene
hsa-mir-32-5p
;
hsa-mir-130b-5p
;
hsa-mir-125b-5p
;
hsa-mir-218-5p
;
hsa-mir-129-5p
;
hsa-mir-507
;
hsa-mir-557
;
hsa-mir-10a-3p
;
hsa-mir-26a-2-3p
;
hsa-mir-526b-5p
;
hsa-mir-6885-3p
;
hsa-mir-3680-3p
;
hsa-mir-450b-5p
;
hsa-mir-33b-5p
;
hsa-mir-33a-5p
;
hsa-mir-3140-3p
;
hsa-mir-6844
;
hsa-mir-4748
;
hsa-mir-5572
;
hsa-mir-4260
;
hsa-mir-450a-2-3p
;
hsa-mir-5587-5p
;
hsa-mir-6857-5p
;
hsa-mir-6763-5p
;
hsa-mir-3150a-3p
;
hsa-mir-6810-5p
;
hsa-mir-2110
;
hsa-mir-197-3p
;
hsa-mir-6740-5p
;
hsa-mir-6825-5p
;
hsa-mir-939-5p
;
hsa-mir-1343-5p
;
hsa-mir-3175
;
hsa-mir-6883-5p
;
hsa-mir-6785-5p
;
hsa-mir-4728-5p
;
hsa-mir-149-3p
;
hsa-mir-6797-5p
;
hsa-mir-1249-5p
;
hsa-mir-6875-5p
;
hsa-mir-3126-5p
;
hsa-mir-7845-5p
;
hsa-mir-5003-3p
;
hsa-mir-190a-5p
;
hsa-mir-190b
Nearest miRNA
hsa-mir-10398/Upstream/65399; hsa-mir-1202/Downstream/194329;
Nearest TSS
ENST00000381078/Upstream/17635;
ENST00000447508/Downstream/5790;
Nearest CpG islands
None/Target,
chr6-CpG: 120/Upstream/726948
,
chr6-CpG: 35/Downstream/9780
Upstream sequence
TTCAGTTTCGTCTAAAAGTAACAAACATCCTTCCCCCAACTTCTCCTCCTACCCATGAACTAGGAGGGAGAAACCTAAGACAAATTAAAAAACTAAGTGA
Downstream sequence
TTTGCAAAGGGTGGGTGGGGGGAAGAGTAAGAAAACTCCCCCAGGAGAAGTAttgggtcgctgcaaaagtaaccgcaggtctttccattactttcaaagg
Target sequence
GGCATGAAATCAGATGTTTCCCTCAACAAGTTTCAGTCAGGAAATACTGACAGGGAAGAGGAAGTTTTCAATGCACAGGCTTCTCCTCTGCCTGCCAGGAGCTATTTTTTCTGTGGTGGGGTCGAGGGTGGTCCTATACGACCACACACACCCAACACATAACTCCAACTCAAAAACCCATACTGTGGCCACTATTTTGGAAGTAGTAATGGTTGGA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT1
Sample type
PBMC
Age
47
Gender
Male
CpG Island Information
×
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