Basic Information
VIS ID
TVIS30016469
Fusion event
HIV-BCLAF1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
136604960/136283822 (Hg38)
End
136605078/136283822 (Hg38)
Orient
+
Location type
Intronic
Target gene
BCLAF1
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-877-3p ; hsa-mir-423-5p ; hsa-mir-342-5p ; hsa-mir-22-5p ; hsa-mir-615-3p ; hsa-mir-26b-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-142-3p ; hsa-mir-561-3p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-548n ; hsa-mir-424-3p ; hsa-mir-146a-5p ; hsa-mir-194-5p
Nearest miRNA
hsa-mir-10398/Upstream/1044566; hsa-mir-1202/Downstream/2151391;
Nearest TSS
ENST00000381078/Upstream/3956; ENST00000607749/Downstream/5959;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/33146, chr6-CpG: 107/Downstream/5188
Upstream sequence
GGTAACATTAAACTGGTGAATCAAGAATAGCGTCTCCTAAAATATCCATGGCCCTCCAACTGGGGAGAGATTTGAGGTTCAGCCTAGGAAGGAGGAATCG
Downstream sequence
CAAGTGGCCAGAGAAAAAAATGGCAATCTTCTAAACTGGAGTACTGTCATAAAACTATTCTGACCTGGAAAGTCATTACTACTGATTCACTCCTAGAAGT
Target sequence
GAACCTATTAAGGGAAACACTAAAAAAGTAGCAAAGTCAAAAAGCCAAGCAAGATTGGGTACAAAAACAAAGGATTTCTAAAGGACATATAAGTTTAGTTTTTAAAATATCAAAACCC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate