Basic Information
VIS ID
TVIS30016471
Fusion event
HIV-UTRN integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
144651568/144330432 (Hg38)
End
144651500/144330432 (Hg38)
Orient
-
Location type
Intronic
Target gene
UTRN
miRNAs that regulate target gene
hsa-mir-206 ; hsa-mir-1-3p ; hsa-mir-21-5p ; hsa-mir-455-3p ; hsa-mir-505-3p ; hsa-mir-484 ; hsa-mir-331-3p ; hsa-let-7b-5p ; hsa-mir-3136-3p ; hsa-mir-4313 ; hsa-mir-26a-2-3p ; hsa-mir-26a-1-3p ; hsa-mir-1915-5p ; hsa-mir-6793-3p ; hsa-mir-4714-3p ; hsa-mir-203b-5p ; hsa-mir-3691-3p ; hsa-mir-556-3p ; hsa-mir-6718-5p ; hsa-mir-6801-5p
Nearest miRNA
hsa-mir-10398/Upstream/3646549; hsa-mir-1202/Downstream/6772243;
Nearest TSS
ENST00000381078/Upstream/38603; ENST00000421035/Downstream/388;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/43288, chr6-CpG: 132/Downstream/1404328
Upstream sequence
GAAGGGGCATGGTTTACCTCTTAGTTTGAGGGCATGTATTATTTAGTGCATTAATGGATGGATCCCTAAAAGCATTAGGAATTAGTCTGGAGTATGTAGG
Downstream sequence
TTGAAAAATAGGTTATAAAATTGATGAGAACAAGCTCTCTTGCAAGAGTTAGAAACATAAAAACAAATTTTTCTAAAGCTAAATTCCTTAACATTTTTCC
Target sequence
CATGTATTATTTAGTGCATTAATGGATGGATCCCTAAAAGCATTAGGAATTAGTCTGGAGTATGTAGG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate