Basic Information
VIS ID
TVIS30016474
Fusion event
HIV-LATS1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
150015152/149694016 (Hg38)
End
150015179/149694016 (Hg38)
Orient
+
Location type
Intronic
Target gene
LATS1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-103a-3p ; hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-4279 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-3691-3p ; hsa-mir-5697 ; hsa-mir-122-3p ; hsa-mir-5581-5p ; hsa-mir-4297 ; hsa-mir-3614-3p
Nearest miRNA
hsa-mir-10398/Upstream/9010133; hsa-mir-1202/Downstream/1408659;
Nearest TSS
ENST00000381078/Upstream/45044; ENST00000623174/Downstream/7947;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/45180, chr6-CpG: 79/Downstream/23512
Nearest cancer related gene
LATS1(TSG, No orient, 0)
Upstream sequence
ccgtctctactaaaaatacaaaaaattagccgggcatagtggcgggcacctgtaatcccagctacttgtgggctggggcaggagaactgcttgaacctgg
Downstream sequence
cataccactgtactccagcctgggcaacagagtgaaactccatctcaaaaaaataaaaaaataaaataataaattggtgctatctttctagacagcaata
Target sequence
gatgcagaggttgcagtgagctgagaa
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate